Madonna has hit back at claims by DJ Deadmau5 that she glamorised drug use during a concert in Florida over the weekend.
The world-famous music guru branded the Material Girl a "f****g idiot" after she asked the crowd how many of them had "met molly" as she introduced Swedish DJ Avicii to the stage at the Ultra Music Festival in Miami on Saturday.
While "molly" is a slang term for the active ingredient in ecstasy, Madge insists her comments have been taken the wrong way.
The 53-year-old singer took to Twitter, posting a Photoshopped picture of herself wearing Minnie Mouse ears.
"From one mouse to another I dont support drug use and i never have," the Daily Mail quoted her as tweeting.
"I was referring to the song called Have You Seen Molly written by my friend Cedric Gervaiswho I almost worked with on my album," she tweeted.
Deadmau5, whose real name Joel Thomas Zimmerman, responded to the tweet.
"Fair enough, I was just voicing my concerns as I usually do. +1 respect for clearing it up personally... regardless, just be a little more aware of what you should represent at EDM events, and I'll watch my mouth," he tweeted.
Madonna, getting the final word, responded again.
"Communication is always best. You should have called me first, we could have cleared it up 'privately.' ;) See you on the road," she tweeted.
DeadMau5, whose moniker is pronounced dead mouse, had initially tweeted about the singer asking the question on stage.
"Very classy there Madonna. "HUR DUR HAS ANYONE SEEN MOLLY???" he tweeted.
"Such a great message for the young music lovers at ultra. quite the f***n philanthropist. but hey, at least yer HIP AND TRENDY! F*****g cant smack my head hard enough right now," he said.
The star, who performs while wearing a plastic mouse head, continued to rant against the star's behaviour after receiving complaints from people defending her outburst.
"seriously, 'I giveth not a f***ing single F*** for slating on Madonna for reaching an entirely NEW level of idiocy.
"I can appreciate her meteoric career, and all good deeds done, but WHAT THE F*** WAS THAT?
"That's your big contribution to EDM [electronic dance music]?
"Thats your big message to ultra attendies? hipsterspeak for looking for drugs? f*** off you f***ing IDIOT," he said.
But the award winning house producer was not finished, and after calming down, wrote a lengthy blog entry where he explained he was unhappy she was abusing her power and not acting responsibly.
"We have, and will always have personal choice. Thats how our lives are shaped... through the good or bad choices we make.
"We learn every day from them, but they're ours to make, and its our responsibility to make the right ones for each of ourselves.
"Not to be pandered down to us in metaphorical pill form from BIG voices as a marketing scheme to "fit in" with todays young and "hip" crowd to sell a f***ing CD.
"So, if you can be pandered with MDNA references, then at least pander your own ass with a good sense of responsibility which will enable you to make the personal choices that are right for YOU," he added.